Effect sizes for categorical risk factors will be expressed as odds ratios with 95% confidence intervals. Meta-analysis using random-effects model will be performed using Review Manager 5.3. All studies selected for data extraction will be critically appraised for methodological quality. Data relevant to exposures and outcomes will be extracted from all included studies. All identified studies will be screened for title and abstract and full-text against the inclusion criteria on Covidence software. Databases to be searched include PubMed, CINAHL, Embase, Web of Science, and grey literature (Google Scholar). This review will include all comparative observational studies conducted in adults aged >18 years with confirmed diagnosis of PCAD (on angiography) compared to those without PCAD. Objective of this review is to compare modifiable and non-modifiable risk factors for PCAD compared to those without PCAD. PCAD possesses a public health challenge resulting in years of productive life lost and an escalating burden on health systems.
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